![]() ![]() HR: 3.27 95% CI: 1.96 to 5.45 p < 0.0001) was higher for women as compared with men.Īmong individuals without known CAD, nonobstructive and obstructive CAD by CCTA are associated with higher rates of mortality, with risk profiles differing for age and sex. When stratified by age <65 years versus ≥65 years, younger patients experienced higher hazards for death for 2-vessel (HR: 4.00 95% CI: 2.16 to 7.40 p < 0.0001 vs. Importantly, the absence of CAD by CCTA was associated with a low rate of incident death (annualized death rate: 0.28%). Incident mortality was associated with a dose-response relationship to the number of coronary vessels exhibiting obstructive CAD, with increasing risk observed for nonobstructive (HR: 1.62 95% CI: 1.20 to 2.19 p = 0.002), obstructive 1-vessel (HR: 2.00 95% CI: 1.43 to 2.82 p < 0.0001), 2-vessel (HR: 2.92 95% CI: 2.00 to 4.25 p < 0.0001), or 3-vessel or left main (HR: 3.70 95% CI: 2.58 to 5.29 p < 0.0001) CAD. ![]() In risk-adjusted analysis, both per-patient obstructive (hazard ratio : 2.60 95% confidence interval : 1.94 to 3.49 p < 0.0001) and nonobstructive (HR: 1.60 95% CI: 1.18 to 2.16 p = 0.002) CAD conferred increased risk of mortality compared with patients without evident CAD. Time to mortality was estimated using multivariable Cox proportional hazards models.Īt a 2.3 ± 1.1-year follow-up, 404 deaths had occurred. CAD severity was judged on a per-patient, per-vessel, and per-segment basis. In these patients, CAD by CCTA was defined as none (0% stenosis), mild (1% to 49% stenosis), moderate (50% to 69% stenosis), or severe (≥70% stenosis). We evaluated a consecutive cohort of 24,775 patients undergoing ≥64-detector row CCTA between 20 without known CAD who met inclusion criteria. We examined mortality in relation to coronary artery disease (CAD) as assessed by ≥64-detector row coronary computed tomography angiography (CCTA).Īlthough CCTA has demonstrated high diagnostic performance for detection and exclusion of obstructive CAD, the prognostic findings of CAD by CCTA have not, to date, been examined for age- and sex-specific outcomes. ![]()
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